2024

CRISP’edit

Asencio C, Hervé P, Morand P, Oliveres Q, Morel CA, Prouzet-Mauleon V, Biran M, Monic S, Bonhivers M, Robinson DR, Ouellette M, Rivière L, Bringaud F, Tetaud E. Streptococcus pyogenes Cas9 ribonucleoprotein delivery for efficient, rapid and marker-free gene editing in Trypanosoma and Leishmania. Mol Microbiol. 2024 Apr 1. [PubMed]

SAM

Bagdadi N, Wu J, Delaroche J, Serre L, Delphin C, De Andrade M, Carcel M, Nawabi H, Pinson B, Vérin C, Couté Y, Gory-Fauré S, Andrieux A, Stoppin-Mellet V, Arnal I. Stable GDP-tubulin islands rescue dynamic microtubules. J Cell Biol. 2024 Aug 5;223(8):e202307074. doi: 10.1083/jcb.202307074. Epub 2024 May 17. PMID: 38758215

Vect’UB

Boutin J, Genevois C, Couillaud F, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Amintas S, Moranvillier I, Richard E, Blouin JM, Dabernat S, Moreau-Gaudry F, Bedel A. CRISPR editing to mimic porphyria combined with light: A new preclinical approach for prostate cancer. Mol Ther Oncol. 2024 Feb 8;32(1):200772. [PubMed]

Boutin J, Genevois C, Couillaud F, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Amintas S, Moranvillier I, Richard E, Blouin JM, Dabernat S, Moreau-Gaudry F, Bedel A. CRISPR editing to mimic porphyria combined with light: A new preclinical approach for prostate cancer. Mol Ther Oncol. 2024 Feb 8;32(1):200772. [PubMed]

Oncoprot

Basbous S, Dif L, Dantzer C, Di-Tommaso S, Dupuy JW, Bioulac-Sage P, Raymond AA, Desdouets C, Saltel F, Moreau V. Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma. Cell Death Dis. 2024 Jan 13;15(1):46. [PubMed]

Seeneevassen L, Zaafour A, Sifré E, Genevois C, Nguyen TL, Pobiedonoscew Y, Giese A, Guignard J, Tiffon C, Rousseau B, Raymond AA, Belleannée G, Boeuf H, Gronnier C, Martin OCB, Giraud J, Lehours P, Dubus P, Varon C. Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor. Cell Death Discov. 2024 Mar 7;10(1):120. [PubMed]

VIVOPTIC

Mazzocco C, Genevois C, Li Q, Doudnikoff E, Dutheil N, Leste-Lasserre T, Arotcarena ML, Bezard E. In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression. Sci Rep. 2024 Apr 27;14(1):9710. [PubMed].

Boutin J, Genevois C, Couillaud F, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Amintas S, Moranvillier I, Richard E, Blouin JM, Dabernat S, Moreau-Gaudry F, Bedel A. CRISPR editing to mimic porphyria combined with light: A new preclinical approach for prostate cancer. Mol Ther Oncol. 2024 Feb 8;32(1):200772. [PubMed].

Seeneevassen L, Zaafour A, Sifré E, Genevois C, Nguyen TL, Pobiedonoscew Y, Giese A, Guignard J, Tiffon C, Rousseau B, Raymond AA, Belleannée G, Boeuf H, Gronnier C, Martin OCB, Giraud J, Lehours P, Dubus P, Varon C. Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor. Cell Death Discov. 2024 Mar 7;10(1):120. [PubMed]

Zaafour A, Seeneevassen L, Nguyen TL, Genevois C, Nicolas N, Sifré E, Giese A, Porcheron C, Descarpentrie J, Dubus P, Khatib AM, Varon C. Inhibition of proprotein convertases activity results in repressed stemness and invasiveness of cancer stem cells in gastric cancer. Gastric Cancer. 2024 Mar;27(2):292-307. [PubMed].

OneCell

HBS1+ myeloid cells expand in SLD hepatocellular carcinoma andcontribute to immunosuppression and unfavorable prognosis through TREM1 Julie Giraud, Domitille Chalopin, Eloïse Ramel, Marc Derive, Macha Nikolski, Maya Saleh Cell Report, Open AccessPublished:February 12, 2024 doi.org/10.1016/j.celrep.2024.11377 [PubMed]

VoxCell

Maurat E, Raasch K,  Leipold A, Henrot P, Zysman M, Prevel R, Trian T, Krammer T, Bergeron V, Thumerel M, Nassoy P, Berger P, Saliba AE, Andrique L, Recher G, Dupin I. A novel in vitro tubular model to recapitulate features of distal airways: the bronchioid. European Respiratory Journal. 2024, under review.

Bertillot F, Andrique L, Ureña Martin C, Zajac O, de Plater L, Norton MM, Richard A, Alessandri K, Gurchenkov BG, Fage F, Asnacios A, Lamaze C, Das M, Maître JL, Nassoy P, Matic Vignjevic D. Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization. Commun Biol. 2024 Feb 15;7(1):184.

FACSility

Domblides C, Crampton S, Liu H, Bartleson JM, Nguyen A, Champagne C, Landy EE, Spiker L, Proffitt C, Bhattarai S, P Grawe A, Fuentealba Valenzuela M, Lartigue L, Mahouche I, Dupaul-Chicoine J, Nishimura K, Lefort F, Decraecker M, Velasco V, Netzer S, Pitard V, Roy C, Soubeyran I, Racine V, Blanco P, Déchanet-Merville J, Saleh M, Canna SW, Furman D, Faustin B. Human NLRC4 promotes cancer survival and is associated to type-I interferon signaling and immune infiltration. J Clin Invest. 2024 Apr 23;134(11):e166085. [PubMed]

Garcia G, Labrouche-Colomer S, Duvignaud A, Clequin E, Dussiau C, Trégouët DA, Malvy D, Prevel R, Zouine A, Pellegrin I, Goret J, Mamani-Matsuda M, Dewitte A, James C. Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease. J Transl Med. 2024 Mar 7;22(1):246. [PubMed]

Giraud J, Chalopin D, Ramel E, Boyer T, Zouine A, Derieppe MA, Larmonier N, Adotevi O, Le Bail B, Blanc JF, Laurent C, Chiche L, Derive M, Nikolski M, Saleh M. THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1. Cell Rep. 2024 Feb 27;43(2):113773 [PubMed]

Garreau A, Santa P, Dubois M, Brisou D, Levionnois É, Laurent P, Ferriere A, Roubertie A, Loizon S, Duluc D, Blanco P, Contin-Bordes C, Truchetet ME, Sisirak V. The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease. Eur J Immunol. 2024 Apr 4:e2350903. [PubMed]

2023

CRISP’edit

Gounou C, Rouyer L, Siegfried G, Harté E, Bouvet F, d’Agata L, Darbo E, Lefeuvre M, Derieppe MA, Bouton L, Mélane M, Chapeau D, Martineau J, Prouzet-Mauleon V, Tan S, Souleyreau W, Saltel F, Argoul F, Khatib AM, Brisson AR, Iggo R, Bouter A. Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis. Cell Mol Life Sci. 2023 Dec 13;81(1):7 [PubMed]

Gounou C, Bouvet F, Liet B, Prouzet-Mauléon V, d’Agata L, Harté E, Argoul F, Siegfried G, Iggo R, Khatib AM, Bouter A. Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish. Biol Cell. 2023 Jun;115(6):e202200110 [PubMed]

Cullot G, Amintas S, Karembé L, Prouzet-Mauléon V, Rébillard J, Boureau L, Cappellen D, Bedel A, Moreau-Gaudry F, Dulucq S, Dabernat S, Turcq B. Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR Rearrangements. CRISPR J. 2023 Apr;6(2):140-151 [PubMed]

SAM

Pinson B, Moenner M, Saint-Marc C, Granger-Farbos A, Daignan-Fornier B. On-demand utilization of phosphoribosyl pyrophosphate by downstream anabolic pathways. J Biol Chem. 2023 Aug;299(8):105011. doi: 10.1016/j.jbc.2023.105011. Epub 2023 Jul 4. PMID: 37414150 Free PMC article.

Guerville F, Vialemaringe M, Cognet C, Duffau P, Lazaro E, Cazanave C, Bonnet F, Leleux O, Rossignol R, Pinson B, Tumiotto C, Gabriel F, Appay V, Déchanet-Merville J, Wittkop L, Faustin B, Pellegrin I; on the behalf of ANRS CO3 Aquitaine / AquiVIH-NA study group. Mechanisms of systemic low-grade inflammation in HIV patients on long-term suppressive antiretroviral therapy: the inflammasome hypothesis. AIDS. 2023 Jun 1;37(7):1035-1046. doi: 10.1097/QAD.0000000000003546. Epub 2023 Mar 14. PMID: 36928274

Tingaud-Sequeira A, Mercier E, Michaud V, Pinson B, Gazova I, Gontier E, Decoeur F, McKie L, Jackson IJ, Arveiler B, Javerzat S. The Dct-/- Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism. Genes (Basel). 2022 Jun 27;13(7):1164. doi: 10.3390/genes13071164. PMID: 35885947 Free PMC article.

Vect’UB

Cullot G, Boutin J, Fayet S, Prat F, Rosier J, Cappellen D, Lamrissi I, Pennamen P, Bouron J, Amintas S, Thibault C, Moranvillier I, Laharanne E, Merlio JP, Guyonnet-Duperat V, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9. Nat Commun. 2023 Jul 10;14(1):4072. [PubMed]

Boileau C, Deforges S, Peret A, Scavarda D, Bartolomei F, Giles A, Partouche N, Gautron J, Viotti J, Janowitz H, Penchet G, Marchal C, Lagarde S, Trebuchon A, Villeneuve N, Rumi J, Marissal T, Khazipov R, Khalilov I, Martineau F, Maréchal M, Lepine A, Milh M, Figarella-Branger D, Dougy E, Tong S, Appay R, Baudouin S, Mercer A, Smith JB, Danos O, Porter R, Mulle C, Crépel V. GluK2 Is a Target for Gene Therapy in Drug-Resistant Temporal Lobe Epilepsy. Ann Neurol. 2023 Oct;94(4):745-761. [PubMed]

Pinson B, Moenner M, Saint-Marc C, Granger-Farbos A, Daignan-Fornier B. On-demand utilization of phosphoribosyl pyrophosphate by downstream anabolic pathways. J Biol Chem. 2023 Aug;299(8):105011. .[PubMed]

Oncoprot

Park DS, Kozaki T, Tiwari SK, Moreira M, Khalilnezhad A, Torta F, Olivié N, Thiam CH, Liani O, Silvin A, Phoo WW, Gao L, Triebl A, Tham WK, Gonçalves L, Kong WT, Raman S, Zhang XM, Dunsmore G, Dutertre CA, Lee S, Ong JM, Balachander A, Khalilnezhad S, Lum J, Duan K, Lim ZM, Tan L, Low I, Utami KH, Yeo XY, Di Tommaso S, Dupuy JW, Varga B, Karadottir RT, Madathummal MC, Bonne I, Malleret B, Binte ZY, Wei Da N, Tan Y, Wong WJ, Zhang J, Chen J, Sobota RM, Howland SW, Ng LG, Saltel F, Castel D, Grill J, Minard V, Albani S, Chan JKY, Thion MS, Jung SY, Wenk MR, Pouladi MA, Pasqualini C, Angeli V, Cexus ONF, Ginhoux F. iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer. Nature. 2023 Nov 1. [PubMed].

Lavie J, Lalou C, Mahfouf W, Dupuy JW, Lacaule A, Cywinska AA, Lacombe D, Duchêne AM, Raymond AA, Rezvani HR, Ngondo RP, Bénard G. The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins. Cell Rep. 2023 May 31;42(6):112579. [PubMed]

Di Tommaso S, Dourthe C, Dupuy JW, Dugot-Senant N, Cappellen D, Cazier H, Paradis V, Blanc JF, Le Bail B, Balabaud C, Bioulac-Sage P, Saltel F, Raymond AA. Spatial characterisation of β-catenin-mutated hepatocellular adenoma subtypes by proteomic profiling of the tumour rim. JHEP Rep. 2023 Sep 22;6(2):100913. [PubMed]

VIVOPTIC

Curcio A, Perez JE, Prévéral S, Fromain A, Genevois C, Michel A, Van de Walle A, Lalatonne Y, Faivre D, Ménager C, Wilhelm C. The role of tumor model in magnetic targeting of magnetosomes and ultramagnetic liposomes. Sci Rep. 2023 Feb 8;13(1):2278. [PubMed].

OneCell

hepatocellular carcinoma Camille Dantzer, Justine Vaché, Aude Brunel, Isabelle Mahouche, Anne-Aurélie Raymond, Jean-William Dupuy, Melina Petrel, Paulette Bioulac-Sage, David Perrais, Nathalie Dugot-Senant, Mireille Verdier, Barbara Bessette, Clotilde Billottet, Violaine Moreau doi: https://doi.org/10.1101/2023.10.24.563805

Stem cell decoupling underlies impaired lymphoid developmentduring aging Geunhyo Jang, Stephania Contreras Castillo, Eduardo Esteva, Samik Upadhaya,Jue Feng, Nicholas M Adams, Elodie Richard, Rajeshwar Awatramani, Catherine M Sawai, Boris Reizis Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2302019120.DOI: 10.1073/pnas.2302019120 [PubMed]

FACSility

Cullot G, Amintas S, Karembé L, Prouzet-Mauléon V, Rébillard J, Boureau L, Cappellen D, Bedel A, Moreau-Gaudry F, Dulucq S, Dabernat S, Turcq B. Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR Rearrangements. CRISPR J. 2023 Apr;6(2):140-151 [PubMed]

Prochazkova-Carlotti M, Gros A, Richard E, Cherrier F, Laharanne E, Idrissi Y, Baron C, Poglio S, Ducharme O, Menguy S, Pham-Ledard A, Beylot-Barry M, Merlio JP, Bresson-Bepoldin L. Patient-Derived Xenograft and Cell Line Models of Human Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type. J Invest Dermatol. 2023 Feb;143(2):340-344.e6. [PubMed]

Arricau-Bouvery N, Dubrana MP, Canuto F, Duret S, Brocard L, Claverol S, Malembic-Maher S, Foissac X. Flavescence dorée phytoplasma enters insect cells by a clathrin-mediated endocytosis allowing infection of its insect vector. Sci Rep. 2023 Feb 7;13(1):2211 [PubMed]

Le Saos-Patrinos C, Loizon S, Zouine A, Turpin D, Dilhuydy MS, Blanco P, Sisirak V, Forcade E, Duluc D. Elevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion. J Leukoc Biol. 2023 Mar 1;113(3):305-314. [PubMed]

Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I. Chaperone-mediated autophagy protects against hyperglycemic stress. Autophagy. 2024 Apr;20(4):752-768 [PubMed]

Nguyen Ky M, Duran A, Hasantari I, Bru A, Deloire M, Brochet B, Ruet A, Schmitt N. Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin β7+ Compartment. Neurol Neuroimmunol Neuroinflamm. 2023 Sep 22;10(6):e200166. [PubMed]

UB’L3

De Rache A, Marquevielle J, Bouaziz S, Vialet B, Andreola ML, Mergny JL, Amrane S. Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter. J Mol Biol. 2024 Jan 15;436(2):168359. [PubMed]

Abou-Hamdan M, Saleh R, Mani S, Dournaud P, Metifiot M, Blondot ML, Andreola ML, Abdel-Sater F, De Reggi M, Gressens P, Laforge M. Potential antiviral effects of pantethine against SARS-CoV-2. Sci Rep. 2023 Feb 8;13(1):2237. [PubMed]

2022

CRISP’edit

Sannino A, Scarfì MR, Dufossée M, Romeo S, Poeta L, Prouzet-Mauléon V, Priault M, Zeni O. Inhibition of Autophagy Negates Radiofrequency-Induced Adaptive Response in SH-SY5Y Neuroblastoma Cells. Int J Mol Sci. 2022 Jul 29;23(15):8414 [PubMed]

SAM

Orieux A, Brunier J, Rigothier C, Pinson B, Dabernat S, Bats ML. Plasma creatinine below limit of quantification in a patient with acute kidney injury. Clin Chim Acta. 2022 Jan 1;524:101-105. doi: 10.1016/j.cca.2021.12.001. Epub 2021 Dec 6. PMID: 34883091

Kaminski H, Marseres G, Yared N, Nokin MJ, Pitard V, Zouine A, Garrigue I, Loizon S, Capone M, Gauthereau X, Mamani-Matsuda M, Coueron R, Durán RV, Pinson B, Pellegrin I, Thiébaut R, Couzi L, Merville P, Déchanet-Merville J. mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation. J Am Soc Nephrol. 2022 Jan;33(1):121-137. doi: 10.1681/ASN.2020121753. Epub 2021 Nov 1. PMID: 34725108 Free PMC article. Clinical Trial.

Vect’UB

Lapaillerie D, Charlier C, Guyonnet-Dupérat V, Murigneux E, Fernandes HS, Martins FG, Magalhães RP, Vieira TF, Richetta C, Subra F, Lebourgeois S, Charpentier C, Descamps D, Visseaux B, Weigel P, Favereaux A, Beauvineau C, Buron F, Teulade-Fichou MP, Routier S, Gallois-Montbrun S, Meertens L, Delelis O, Sousa SF, Parissi V. Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0008322.[PubMed]

Dard L, Hubert C, Esteves P, Blanchard W, Bou About G, Baldasseroni L, Dumon E, Angelini C, Delourme M, Guyonnet-Dupérat V, Claverol S, Fontenille L, Kissa K, Séguéla PE, Thambo JB, Nicolas L, Herault Y, Bellance N, Dias Amoedo N, Magdinier F, Sorg T, Lacombe D, Rossignol R. HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models. J Clin Invest. 2022 Apr 15;132(8):e131053. [PubMed]

Rahal F, Capdevielle C, Rousseau B, Izotte J, Dupuy JW, Cappellen D, Chotard G, Ménard M, Charpentier J, Jecko V, Caumont C, Gimbert E, Grosset CF, Hagedorn M. An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect. Neurooncol Adv. 2022 Mar 1;4(1):vdac018. [PubMed]

Dupont M, Huart M, Lauvinerie C, Bidet A, Guitart AV, Villacreces A, Vigon I, Desplat V, El Habhab A, Pigneux A, Ivanovic Z, Brunet De la Grange P, Dumas PY, Pasquet JM. Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells. Cancers (Basel). 2022 Jan 17;14(2):453. [PubMed]

Lambert E, Saha O, Soares Landeira B, Melo de Farias AR, Hermant X, Carrier A, Pelletier A, Gadaut J, Davoine L, Dupont C, Amouyel P, Bonnefond A, Lafont F, Abdelfettah F, Verstreken P, Chapuis J, Barois N, Delahaye F, Dermaut B, Lambert JC, Costa MR, Dourlen P. The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects. Acta Neuropathol Commun. 2022 Jan 8;10(1):4. [PubMed]

Basbous S, Paysan L, Sena S, Allain N, Hiriart JB, Dugot-Senant N, Rousseau B, Chevret E, Lagrée V, Moreau V. Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence. Cancer Gene Ther. 2022 May;29(5):437-444. [PubMed]

Oncoprot

Chauveau B, Garric A, Di Tommaso S, Raymond AA, Visentin J, Vermorel A, Dugot-Senant N, Déchanet-Merville J, Duong Van Huyen JP, Rabant M, Couzi L, Saltel F, Merville P. WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation. Sci Rep. 2022 Nov 9;12(1):19094. [PubMed]

Sala M, Allain N, Moreau M, Jabouille A, Henriet E, Abou-Hammoud A, Uguen A, Di-Tommaso S, Dourthe C, Raymond AA, Dupuy JW, Gerard E, Dugot-Senant N, Rousseau B, Merlio JP, Pham-Ledart A, Vergier B, Tartare-Deckert S, Moreau V, Saltel F. Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation. Oncogene. 2022 Apr;41(18):2571-2586. [PubMed]

Chauveau B, Raymond AA, Di Tommaso S, Visentin J, Vermorel A, Dugot-Senant N, Dourthe C, Dupuy JW, Déchanet-Merville J, Duong Van Huyen JP, Rabant M, Couzi L, Saltel F, Merville P. The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy. Biomedicines. 2022 Feb 28;10(3):569. [PubMed]

VIVOPTIC

Pauline Jeanjean, Dounia El Hamrani, Coralie Genevois, Bruno Quesson, and Franck Couillaud. Combination of MRI-Guided High-Intensity Focused Ultrasound and Bioluminescent Biological Systems to Assess Thermal Therapies for Tumor and Tumor Microenvironment. Advanced Materials Technologies. 2022 July.

Gaillard M, Parlanti E, Sourzac M, Couillaud F, Genevois C, Boutry S, Rigaud C, Daverat F. New insights into detecting alizarin from autofluorescence in marked glass eels. Sci Rep. 2022 Sep 26;12(1):15985. [PubMed].

OneCell

Long-lived central memory γδ T cells confer protection against murine cytomegalovirus reinfectionNathalie Yared, Maria Papadopoulou, Sonia Netzer, Laure Burguet, Lea Mora Charrot, Benoit Rousseau, Atika Zouine, Xavier Gauthereau, David Vermijlen, Julie Déchanet-Merville, View ORCID ProfileMyriam Capone doi: https://doi.org/10.1101/2022.08.05.502906

VoxCell

Recher G, Mombereau A, Boyreau A, Nassoy P, Andrique L. Production d’organoïdes tumoraux 3D par la technologie des capsules cellulaires TCC [3D Tumor organoid models produced by cellular capsules technology CCT]. Bull Cancer. 2022 Jan;109(1):38-48.

CellOxia

Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells. Dupont M, Huart M, Lauvinerie C, Bidet A, Guitart AV, Villacreces A, Vigon I, Desplat V, El Habhab A, Pigneux A, Ivanovic Z, Brunet De la Grange P, Dumas PY, Pasquet JM. Cancers (Basel). 2022 Jan 17;14(2):453. doi: 10.3390/cancers14020453. PMID: 35053612

UB’L3

Amrane S, Jaubert C, Bedrat A, Rundstadler T, Recordon-Pinson P, Aknin C, Guédin A, De Rache A, Bartolucci L, Diene I, Lemoine F, Gascuel O, Pratviel G, Mergny JL, Andreola ML. Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection. Nucleic Acids Res. 2022 Nov 28;50(21):12328-12343. [PubMed]

Beucher G, Blondot ML, Celle A, Pied N, Recordon-Pinson P, Esteves P, Faure M, Métifiot M, Lacomme S, Dacheux D, Robinson DR, Längst G, Beaufils F, Lafon ME, Berger P, Landry M, Malvy D, Trian T, Andreola ML*, Wodrich H*. Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2202370119. [PubMed]

FACSility

Kaminski H, Marseres G, Yared N, Nokin MJ, Pitard V, Zouine A, Garrigue I, Loizon S, Capone M, Gauthereau X, Mamani-Matsuda M, Coueron R, Durán RV, Pinson B, Pellegrin I, Thiébaut R, Couzi L, Merville P, Déchanet-Merville J. mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation. J Am Soc Nephrol. 2022 Jan;33(1):121-137 [PubMed]

Dupont M, Huart M, Lauvinerie C, Bidet A, Guitart AV, Villacreces A, Vigon I, Desplat V, El Habhab A, Pigneux A, Ivanovic Z, Brunet De la Grange P, Dumas PY, Pasquet JM. Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells. Cancers (Basel). 2022 Jan 17;14(2):453. [PubMed]

Hobson BD, Kong L, Angelo MF, Lieberman OJ, Mosharov EV, Herzog E, Sulzer D, Sims PA. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell Rep. 2022 Jan 11;38(2):110208. [PubMed]

Celle A, Esteves P, Cardouat G, Beaufils F, Eyraud E, Dupin I, Maurat E, Lacomme S, Ousova O, Begueret H, Thumerel M, Marthan R, Girodet PO, Berger P, Trian T. Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients. J Allergy Clin Immunol. 2022 Jul;150(1):104-113. [PubMed]

Basbous S, Paysan L, Sena S, Allain N, Hiriart JB, Dugot-Senant N, Rousseau B, Chevret E, Lagrée V, Moreau V. Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence. Cancer Gene Ther. 2022 May;29(5):437-444. [PubMed]

Debeissat C, Avalon M, Huart M, Duchez P, Rodriguez L, Vlaski-Lafarge M, Ivanovic Z, Brunet de la Grange P. Alpha Lipoic-Acid Potentiates Ex Vivo Expansion of Human Steady-State Peripheral Blood Hematopoietic Primitive Cells. Biomolecules. 2022 Mar 11;12(3):431. [PubMed]

Abelanet A, Camoin M, Rubin S, Bougaran P, Delobel V, Pernot M, Forfar I, Guilbeau-Frugier C, Galès C, Bats ML, Renault MA, Dufourcq P, Couffinhal T, Duplàa C. Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction. Arterioscler Thromb Vasc Biol. 2022 Jun;42(6):745-763. [PubMed]

Peru S, Prochazkova-Carlotti M, Cherrier F, Velazquez J, Richard E, Idrissi Y, Cappellen D, Azzi-Martin L, Pham-Ledard A, Beylot-Barry M, Merlio JP, Poglio S. Cutaneous Lymphocyte Antigen Is a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2022 Dec;142(12):3243-3252.e10 [PubMed]

Sannino A, Scarfì MR, Dufossée M, Romeo S, Poeta L, Prouzet-Mauléon V, Priault M, Zeni O. Inhibition of Autophagy Negates Radiofrequency-Induced Adaptive Response in SH-SY5Y Neuroblastoma Cells. Int J Mol Sci. 2022 Jul 29;23(15):8414 [PubMed]

Paget-Blanc V, Pfeffer ME, Pronot M, Lapios P, Angelo MF, Walle R, Cordelières FP, Levet F, Claverol S, Lacomme S, Petrel M, Martin C, Pitard V, De Smedt Peyrusse V, Biederer T, Perrais D, Trifilieff P, Herzog E. A synaptomic analysis reveals dopamine hub synapses in the mouse striatum. Nat Commun. 2022 Jun 3;13(1):3102 [PubMed]

2021

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Mosca N, Khoubai FZ, Fedou S, Carrillo-Reixach J, Caruso S, Del Rio-Alvarez A, Dubois E, Avignon C, Dugot-Senant N, Guettier C, Mussini C, Zucman-Rossi J, Armengol C, Thiébaud P, Veschambre P, Grosset CF. LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways. Liver Cancer. 2021 Dec 21;11(2):126-140. [PubMed]

Boutin J, Rosier J, Cappellen D, Prat F, Toutain J, Pennamen P, Bouron J, Rooryck C, Merlio JP, Lamrissi-Garcia I, Cullot G, Amintas S, Guyonnet-Duperat V, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells. Nat Commun. 2021 Aug 13;12(1):4922. [PubMed]

Lapaillerie D, Charlier C, Fernandes HS, Sousa SF, Lesbats P, Weigel P, Favereaux A, Guyonnet-Duperat V, Parissi V. In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion. Viruses. 2021 Feb 25;13(3):365. [PubMed]

Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R. Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest. 2021 Jan 4;131(1):e133081. [PubMed]

Bakr M, Jullié D, Krapivkina J, Paget-Blanc V, Bouit L, Petersen JD, Retailleau N, Breillat C, Herzog E, Choquet D, Perrais D. The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites. Cell Rep. 2021 Sep 7;36(10):109678. [PubMed]

Dumas PY, Villacreces A, Guitart AV, El-Habhab A, Massara L, Mansier O, Bidet A, Martineau D, Fernandez S, Leguay T, Pigneux A, Vigon I, Pasquet JM, Desplat V. Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia. Clin Cancer Res. 2021 Nov 1;27(21):6012-6025. [PubMed]

Bahri H, Buratto J, Rojo M, Dompierre JP, Salin B, Blancard C, Cuvellier S, Rose M, Ben Ammar Elgaaied A, Tetaud E, di Rago JP, Devin A, Duvezin-Caubet S. TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel. Biochim Biophys Acta Mol Cell Res. 2021 Apr;1868(4):118942. [PubMed]

Chambraud B, Daguinot C, Guillemeau K, Genet M, Dounane O, Meduri G, Poüs C, Baulieu EE, Giustiniani J. Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy. 2021 Nov;17(11):3491-3510. [PubMed]

Moisan F, Oucherif S, Kaulanjan-Checkmodine P, Prey S, Rousseau B, Bonneu M, Claverol S, Gontier E, Lacomme S, Dousset L, Couffinhal T, Toutain J, Loot M, Cario-André M, Jullié ML, Léauté-Labrèze C, Taieb A, Rezvani HR. Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2018690118. [PubMed].

Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J. Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. Mol Psychiatry. 2021 Oct;26(10):5592-5607.[PubMed].

FACSility

Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia. Mol Oncol. 2021 May;15(5):1412-1431. [PubMed]

Kaminski H, Ménard C, El Hayani B, Adjibabi AN, Marsères G, Courant M, Zouine A, Pitard V, Garrigue I, Burrel S, Moreau JF, Couzi L, Visentin J, Merville P, Déchanet-Merville J. Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity. J Infect Dis. 2021 Feb 24;223(4):655-666. [PubMed]

Poglio S, Prochazkova-Carlotti M, Cherrier F, Gros A, Laharanne E, Pham-Ledard A, Beylot-Barry M, Merlio JP. Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity. Leukemia. 2021 Jun;35(6):1696-1709. [PubMed]

Harly C, Joyce SP, Domblides C, Bachelet T, Pitard V, Mannat C, Pappalardo A, Couzi L, Netzer S, Massara L, Obre E, Hawchar O, Lartigue L, Claverol S, Cano C, Moreau JF, Mahouche I, Soubeyran I, Rossignol R, Viollet B, Willcox CR, Mohammed F, Willcox BE, Faustin B, Déchanet-Merville J. Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2. Sci Immunol. 2021 Jul 30;6(61):eaba9010. [PubMed]

Rodriguez L, Duchez P, Touya N, Debeissat C, Guitart AV, Pasquet JM, Vlaski-Lafarge M, Brunet de la Grange P, Ivanovic Z. α-Tocopherol Attenuates Oxidative Phosphorylation of CD34+ Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance. Biomolecules. 2021 Apr 10;11(4):558. [PubMed]

Scherlinger M, Guillotin V, Douchet I, Vacher P, Boizard-Moracchini A, Guegan JP, Garreau A, Merillon N, Vermorel A, Ribeiro E, Machelart I, Lazaro E, Couzi L, Duffau P, Barnetche T, Pellegrin JL, Viallard JF, Saleh M, Schaeverbeke T, Legembre P, Truchetet ME, Dumortier H, Contin-Bordes C, Sisirak V, Richez C, Blanco P. Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis. Sci Transl Med. 2021 Jun 30;13(600):eabi4994 [PubMed]

Henrot P, Beaufils F, Thumerel M, Eyraud E, Boudoussier A, Begueret H, Maurat E, Girodet PO, Marthan R, Berger P, Dupin I, Zysman M. Circulating fibrocytes as a new tool to predict lung cancer progression after surgery? Eur Respir J. 2021 Dec 9;58(6):2101221[PubMed]

Beaufils F, Esteves P, Enaud R, Germande O, Celle A, Marthan R, Trian T, Fayon M, Berger P. Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers. J Allergy Clin Immunol. 2021 Aug;148(2):645-651.e11 [PubMed]

Esteves P, Blanc L, Celle A, Dupin I, Maurat E, Amoedo N, Cardouat G, Ousova O, Gales L, Bellvert F, Begueret H, Thumerel M, Dupuy JW, Desbenoit N, Marthan R, Girodet PO, Rossignol R, Berger P, Trian T. Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling. Eur Respir J. 2021 Nov 25;58(5):2004252. [PubMed]

Boutin J, Rosier J, Cappellen D, Prat F, Toutain J, Pennamen P, Bouron J, Rooryck C, Merlio JP, Lamrissi-Garcia I, Cullot G, Amintas S, Guyonnet-Duperat V, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells. Nat Commun. 2021 Aug 13;12(1):4922. [PubMed]

Dumas PY, Villacreces A, Guitart AV, El-Habhab A, Massara L, Mansier O, Bidet A, Martineau D, Fernandez S, Leguay T, Pigneux A, Vigon I, Pasquet JM, Desplat V. Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia. Clin Cancer Res. 2021 Nov 1;27(21):6012-6025. [PubMed]