SBM department letter #21

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Department activity

At the beginning of the year, changes have taken place for the Department’s Units.
As of now, it is made up of 6 research units and a research support unit:

Biology of Cardiovascular Diseases (BCD) whose director is Thierry Couffinhal
Bordeaux Institute of Oncology (BRIC) whose director is Frédéric Saltel
ImmunoConcEpT whose directress is Julie Déchanet-Merville
Institute of Biochemistry and Cellular Genetics (IBCG) whose directress is Isabelle Sagot
Basic Microbiology an Pathogenicity (BMP) whose director is Frédéric Bringaud
Rare Diseases Genetics and Metabolism (RDGM) whose director is Didier Lacombe
and Biological and Medical Sciences Technologies (TBMCore) whose directress is Béatrice Turcq.

Research building
The move of many teams is planned in a few months. Some pictures of the works progress.

January 18, 2022
Valentin DELOBEL’s seminar

More information >>

February 1st, 2022
Ninon FOUSSARD and Mélody DUFOSSÉE’s seminar

More information >>

Organize a seminar
The Department’s “Seminars and Colloquiums” group offers to organize internal seminars at the Department.
In order to make your requests, please fill out this form and send it to Alexandra Prévot: download the form
Equipments and platforms

Structuring of the TBMCore’s platforms for future joint services

The collaboration between the VoxCell and Histopathology platforms, intitiated a year ago, will give rise to new services during the year 2022.
VoxCell produces cellular organoids in the form of capsules or tubes. These new 3D models, in great demand today, have the advantage of limiting the number of animal experiments. The Histopathology platform allows users to perform experiments ranging from tissue preparation to image capture.
Both platforms have started to develop a specific process allowing the transition between these two platforms. Users will be able to switch from the VoxCell platform with 3D capsule models to the histopathology platform and systemically include their objects and analyze them successfully. Indeed, the classic histology protocols hav been modified in order to be adapted to encapsulated samples.
Supported by the AAP Local structuring actions of the Cancéropôle Grand Sud-Ouest (VoxCell/Histopathology/OncoProt), this structuring will benefit from the help of a contract technician for a year to finalize this development in order to offer users an established service.
The objective of this structuring is first of all to facilitate exchanges between platforms, but also between the users and the different TBMCore platforms, and it can be extended to other TBMCore platforms.

VoxCell platform contact:
Scientific and technical manager:
Laetitia Andrique IR CNRS :

Find out more:

Histpathology platform contact:
Technical manager:

Nathalie Dugot-Senant :

Find out more:


Equipments and platforms

Oncosphere Interdisciplinary Seminar

January 19 – 12:30 p.m.

Pauline Poinot (IC2MP) and Laurent Cronier (STIM) will speak on January 19 at 12 p.m. as part of the Oncosphere interdisciplinary seminars by videoconference.

More information >>


January 20, 2022
Zoom link :

A new opportunity for fruitful exchanges on metabolism, from basic science to clinical research.

For those willing to present their work (oral presentations only), please fill in all sections.
Note that everyone is welcome to present their work, from young scientists (PhD students, post-docs) to senior researchers.

Microbiology Day

March 8, 2022
Agora du Haut-Carré in Talence

Following the success of the second edition of the Microbiology Day in 2021, even during the COVID pandemy, we are organizing the third “Microbiology Day” in 2022. It will take place the 8th of march 2022 at the Agora Haut-Carré in Talence. Call for abstracts and registration are open from today until the 28th of January 2022.

Register >>

CRISPR and Translational Medicine congress

March 31 and April 1st, 2022
Agora du Haut-Carré in Talence

4th SUNRiSE Meeting : New advances in Cancer Stem Cells

June 7 to 9, 2022

CRISPR and Translational Medicine congress

March 31 and April 1st, 2022
Agora du Haut-Carré in Talence


Welcome to the newcomers to the Department!
Alejandra Pando Caciano is a Peruvian doctoral student visiting form January to the end of April within the MIRCADE team (BRIC U1312).

Camille Tocqueville is the new doctoral student supervised by Philippe Veschambre, MIRCADE team (BRIC U1312).

Thibaut Matis joins the Biotherapies Genetics and Oncology BioGO team (BRIC U1312) and begins his thesis as AHU-doc.

Sabrina Fayet recruited IE on fixed-term contract and Jessica Massière, IE University of Bordeaux join the Biotherapies Genetics and Oncology BioGO team (BRIC U1312).


«High Risk – High Gain» cancer research projects on cancers with a poor prognosis.

Application deadline : January 14, 2022
All of the information >>

Prize of the Foundation of France for medical research.

Application deadline : January 19, 2022
All of the information >>

Mourou/Strickland program – Mobility of researchers 2022

Application deadline : February 6, 2022
All of the information >>

Call for applications: The Great French Advances in Biology presented by their authors 2022.

Application deadline : February 11, 2022
All of the information >>

Stay offer for experienced researchers at Churchill College, Cambridge.

Application deadline: February 13, 2022
All of the information >>

Interdisciplinary approaches to oncogenic processes: Functional exploration of the microenvironment of cancers with poor prognosis (MCMP).

Application deadline:February 17, 2022
All of the information >>

Call for transnational projects in personalised medicine – the ERA-NET ERA PerMed- 2022.

Application deadline:February 17, 2022
All of the information >>

Call for projects SIGN’IT 2022 : Signatures in immunotherapy.

Application deadline :March 8 2022
All of the information >>

Call for recurring ANRS projects.

Application dealine :January 15 – March 15 / June 15 – September 15
All of the information >>

Calendar of calls for national cancer research projects of La Ligue Contre Le Cancer.

All of the information >>

Generalist program: Hopes of research.

All of the information >>

Young researchers
Innovation competition i-PhD

Application deadline :March 22, 2022
All of the information >>


On December 13, 2021, the multidisciplinary consortium coordinated by Christpohe Grosset (MIRCADE team, BMGIC – Inserm U1035) published an original article entitled « Deciphering tumour tissue organization by 3D electron microscopy and machine learning » in the Communications Biology journal.

Since 2015, the MIRCADE team (Methods and Innovations for Research on Childhood Cancers) has been studying the biology of several solid tumors in children, including hepatoblastoma, a primary liver cancer. Following observations made in laboratory, Christophe Grosset wondered about the parameters controlling the internal organisation of tumor tissue, knowing that they are very poorly known. To answer this question, he surrounded himself with researchers and engineers from the Departments of Biological and Medical Sciences, Bordeaux Neurocampus and Engineering and Digital Sciences of the University of Bordeaux, including Baudouin Denis De Senneville (Institute of Mathematics), Fatma Zohra Khoubai (MIRCADE team), Jean Ripoche (Inserm, University of Bordeaux), Marc Bevilacqua and Etienne Gontier (Bordeaux Imaging Center, Electron Microscopy Pole). He also approached Alexandre Labedade, independent graphic designer, Christophe Chardot and Sophie Branchereau, both pediatric surgeons at AP-HP, as well as Kathleen Flosseau and Stefano Cairo from XenTech society. After analyses of the biological samples by the « Serial block-face scanning electron microscopy » technique at the BIC and the 3D reconstruction of the tissue by stacking 250 electron microscopy images, the consortium developed a methodology based on the semi-automatic segmentation of the main elements structures of tumor tissue such as blood capillaries, cells, nuclei and mitochondria ( As manual segmentation is too laborious to segment thousands of elements, the consortium traines an artificial neural network of the U-net type for the automatic segmentation of tissue elements, thus generating several training databases (protected by patent). Using this approach, 182 cells, 113 nuclei and 3 portions of a blood capillary were segmented and then analysed using mathematical approaches. The consortium then discovered (i) that blood capillaries and structures near the bile canaliculi influence the planar alignment, polarity and size of tumor cells and their mitochondrial network, and (ii) that the size of hepatoblastoma cells is correlated with that of their nucleus, their cytoplasm and their mitochondrial network. Through this work, the consortium provides some information about the bioarchitectural parameters controlling the 3D organisation of a tumor tissue, thus paving the way for future investigations in an emerging field called « Onconanotomy ».

Zoom on...

BRIC, a unit dedicated to oncology
Started in 2018, the project to structure oncology in Bordeaux has just resulted in the creation of the Inserm U1312 BRIC Unit. Labeled by Inserm and the University of Bordeaux, this research unit brings together all the current strengths of cancer research, namely the former units U1218, U1035, U1053, U1029 and EA 7435. There are therefore 11 teams and more than 230 people who now make up this new Unit.

A Unit to unite forces in oncology

« Born of the desire of the cancer community to restructure, the BRIC Unit – for Bordeaux Institute of Oncology – is a collective project with two mains research themes: cancers with poor prognosis and rare cancers », explains Frédéric Saltel, director of the Unit .

Thus, it is in particular liver cancer, triple negative breast cancer, kidney cancer, leukemia, sarcoma, glioblastoma or even onco-dermatology that are at the center of the laboratory’s research.

The creation of this Unit at the beginning of 2022 marks an important step in the structuring of oncology in Bordeaux, already initiated with the regional network Oncosphère.

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